The targeting construct contains a loxP site in intron 1 and an FRT-loxP-neomycin-FRT-loxP cassette placed in intron 2. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 2 floxed. (J:315006)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count