The targeting construct inserted a loxP site upstream of exon 6, and an FRT-flanked neomycin resistance cassette with a 3' loxP site. Flp-mediated removed the selection cassette and left exon 6 floxed. (J:313623)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count