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CRISPR/Cas9 technology generated an arginine to alanine change at amino acid 38 (R38A) and an arginine to alanine change at amino acid 82 (R82A). Silent mutations to remove the NGG protospacer adjacent motif and introduce restriction enzyme sites were also introduced. These mutations result in loss of heparan sulfate-Tie1 binding. (J:314106)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
