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The targeting construct introduced a loxP site upstream of exon 2 and an FRT-flanked puromycin resistance cassette with a 3 loxP site downstream of exon 2. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2 floxed. Western blot analysis confirmed that both the alpha and beta isoform are no longer expressed. (J:312557)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
