The gene was targeted with two pairs of sgRNAs, up- and downstream of the locus, using CRISPR/Cas9 technology, resulting in the deletion of the locus through various sized deletion-insertions (7638 bp del with 13 bp ins or 7653 bp del with 1 bp ins). (J:311878)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6
Endonuclease-mediated
Insertion, Intergenic deletion, Intragenic deletion
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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