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Exon 5 was replaced with a modified version of the equivalent, but 11 codons longer, exon from the human gene (exon 6). This exon codes for the binding epitope for the OKT3 anti-human CD3E antibody. The modification to the human sequence is the change of an arginine codon at the 3' end of the human exon to the mouse lysine codon. An FRT site flanked puromycin resistance gene cassette that was inserted into an intron, was removed through subsequent flp-mediated recombination. (J:305166)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
