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Proline and arginine (PPRP) codons 91-94 (CCCCCTCGACCG) in exon 2 were targeted for change to glycine-valine-alanine-alanine (GGTGTAGCAGCT)(p.P91_P94delinsGVAA)) with two sgRNAs (targeting GAGCAACAGGAAGCGGTCGA and TTTGAAGAACCCGGAGCAAC) and an ssODN template (GCTACAATGAAACCACTGGGGAGAGGGGAGACTTTCCAGGAACTTACGTTGAATACATTGGAAGGAAAAGAATTTCACCCCCTACTCCCAAGCCTCGGGGTGTAGCAGCTCTTCCTGTTGCTCCGGGTTCTTCAAAAACTGAAGCTGACACGGAGCAGCAAGGTCAGTATGATGAGTGGCTGGTTACTTAATGACCTTTT) using CRISPR/Cas9 technology. The mutation renders the encoded peptide more resistant to cleavage by anthrax lethal toxin. (J:304170)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
