The targeting construct inserted into intron 12 a lox2272 site, inverted exon 12 containing the nucleotide substitutions that results in the amino acid substitution of aspartic acid with lysine at position 495 (E495K), a loxP site, a lox2272 site, and an FRT-flanked neomycin resistance cassette. (J:309176)
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cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count