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An IRES-lacZ gene replaced exons 3-7 via homologous recombination. An inserted neomycin cassette following the IRES-lacZ gene was removed. The insertion of the IRES-lacZ creates a premature termination and results in a peptide containing only the first 137 amino acids. Western blot analysis confirmed that no full-length protein is expressed in homozygous mice and immunofluorescence staining further confirmed absence of protein in embryos. (J:311848)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
