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The transgene insert consists of BAC RP24-238B22, containing the Casp8 gene, which was modified as follows: phage T7 epitope tag coding sequence was inserted upstream of the Casp8 stop codon and an FRT site, an IRES, the GFP green fluorescent protein gene and a second FRT site, were inserted downstream of the stop codon. A twenty nucleotide sequence in intron 1 was replaced with a different sequence of equal length and composition to improve genotyping. (J:140185)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
