The targeting construct introduced loxP site into the promoter region and 3 untranslated region. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of the 3' untranslated region. (J:311843)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count