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CRISPR/Cas9 technology generated acidic amino acid substitutions for basic amino acid residues, arginine and lysine (RK) to glutamate and aspartate (ED), in the putative nuclear localization signal KTRSGKIMRRVLRK. The mRNA levels in the homozygotes are reduced to approximately 50% of levels in wild-type mice while protein levels are reduced more significantly. (J:282290)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
