The targeting construct replaced the coding sequence with a loxP site, FRT-flanked neomycin resistance cassette, the human coding sequence for isoform 3 (E3F) with signal peptide, an F3 flanked puromycin resistance cassette, loxP site, and human GH polyadenylation sequence. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:311531)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NTac
Targeted
Insertion, Intragenic deletion
--
1
7
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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