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EN
Threonine codons 305 and 314 and serine codon 312 were targeted for change to alanine (p.T305A, p.S312A, p.T314A) with a gRNA (targeting ACACCAAGCGGTCTCTGGTAGG) and an ssODN (GAACCAGTGAAAACCAAGACAAGGACTTTTAATGTAAACGCCGGCAGTCTACTCCTGCCTGCTGACGCCAAGCGGTCTCTGGTAGGTGGCTAACCTTTCCTACCGAATCTTGTTTAAGA) using CRISPR/Cas9 technology. These mutations make the encoded amino acids unphosphorylatable. (J:310821)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
