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Using the TARGATT integrase-mediated cassette exchange, the targeting construct containing a bidirectional tetO (TRE) promoter directing the expression of human SHH cDNA and a ZsGreen1 fluorescent marker gene cassette was inserted into Gt(ROSA)26Sor docking attP site using phiC31 integrase. At least three founder lines were generated with line2 and 3 showing similar reporter expressions. Line 2 was used for most of the study. (J:310473)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
