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An A-to-G point mutation (c.707A>G) was engineered in exon 7 to change asparagine codon 236 to a serine codon (p.N236S). The loxP site flanked neomycin resistance gene cassette that was inserted into intron 11 was removed through subsequent cre-mediated recombination. The mutation is found in some human tumors and some tumorigenic mouse cell lines. (J:283471)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
