Log In|Sign Up
EN
CRISPR/cas9 endonuclease-mediated genome editing is used to insert an amino acid substitution at position 82 altering serine to methionine (S82M - AGT to ATG) . The mutation is designed to partially humanize the mouse Ace2 coding sequence in a region important for binding to the SARS-CoV-2 spike protein. (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
