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The targeting vector consists of mouse Dock8 gene encoding exon 3 flanked by two loxP sites, the PGK-neo cassette (Neo) flanked by two flippase recognition target (FRT) sites. After homologous recombination in ES cells and generation of chimeric male founders with correctly targetted ES cells, the PGK-neo cassette was excised by crossing with the CAG-FLPe transgenic mice. Cre-mediated excision of exon 3 results in the appearance of a premature stop codon in exon 4. (J:299945)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
