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The exon 810 of the Optn gene was replaced with a neomycin cassette (Neo) flanked by loxP sites via homologous recombination in ES cells. The absence of Optn protein in the homozygous mice were confirmed by immunoblotting of the lumbar spinal cords. (J:300212)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
