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A mutated form of the human cyclin D1 cDNA, preceded by sequence for a N-terminal 2xFLAG tag and followed by SV40 poly(A) signal sequences, was placed downstream of the mouse mammary tumor virus promoter. The mutation is a G-to-A mutation that changes lysine codon 112 to a glutamic acid codon (p.K112E), eliminating or severely reducing the protein's phosphorylation (kinase) activity. (J:309458)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
