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Most of exon 2 was replaced in-frame by the coding sequence of tau (Mapt) and green fluorescent protein (GFP), followed by translation and transcription termination sequences and the MC1-neomycin cassette. Western blot analysis confirmed the absence of protein in the brain. RT-PCR confirmed the presence of GFP transcripts, however the parkin-tau-GFP fusion protein is not clearly detectable by Western blot or immunohistochemical analysis. (J:309429)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
