The transgenic construct contains the entire ubiquitin protein ligase E3A (Ube3a) gene; it is designed to have a loxp sites flanking exons 3-5. A single FRT site remains just downstream of exon 5 (a remnant of the FRT-flanked zeomycin resistance cassette that was removed by a FLP-expressing plasmid during the BAC recombineering). (J:244070)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count