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CRISPR/cas9 genome editing is used to alter a lysine to glutamic acid mutation at amino acid 302 (K302E ; AAA to GAA) in exon 10. Additionally, the silent nucleotide change N303N (AAC to AAT) was included for targeting efficiency. The substitution results in the expression of Ptprca (CD45.1 or Ly5.1) rather than the Ptprcb (CD45.2 or Ly5.2) allele normally expressed by C57BL/6J mice. (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
