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EN
A vector, which contains (5' to 3') a splice acceptor, floxed neo/stop cassette and sequence encoding mutated nuclear localized lacZ with intragenic duplication corresponding to nucleotides 870-1987 after the ATG such that a shift in codon phase introduces a TGA STOP codon at nucleotide 1993 was inserted into the locus via homologous recombination. The duplication in the lacZ sequence truncated b-galactosidase molecule making the lacZ inactive, except in small fraction of cells undergone infrequent spontaneous random intragenic homologous recombination restoring the functional lacZ sequence. (J:278250)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
