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A targeting vector contained LoxP sites flanking the major coding exon 2 of Hic1, a PGK-neo cassette flanked by FRT sites distal to exon 2 and upstream of the 3' LoxP site. An IRES-NLS-LacZ cassette distal to the 3' LoxP site (downstream of exon 2) was added to enable the efficient identification of Hic1 deleted cells. The male chimeras were bred with female Flippase-expressing mice for deletion of the PGK-neo cassette. (J:292396)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
