A targeting vector containing a 3' FRT flanked neo cassette and P2A-GFP-CreERT2 cassette was inserted to exon 38 of the Lrp4 gene via homologous recombination in C57BL/6J-derived embryonic stem cells. Heterozygous animals were crossed subsequently to FLP recombinase expressing mice to remove the FRT site flanked PGK-neo cassette. (J:291055)