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A targeting vector was designed to insert a frt-flanked neomycin (neo) resistance cassette and loxP upstream of exon 2 of the mouse opioid receptor (Oprm1) gene. The construct was electroporated into 129S6/SvEv -derived embryonic stem (ES) cells SCR012. The resulting mice were crossed with FRT recombinase expression mice to delete the neo cassette. This mouse strain enables the Cre-mediated deletion of exon 2 and exon 3. (J:291061)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
