Oprm1^tm1.1Ygs

A targeting vector was designed to insert a frt-flanked neomycin (neo) resistance cassette and loxP upstream of exon 2 of the mouse opioid receptor (Oprm1) gene. The construct was electroporated into 129S6/SvEv -derived embryonic stem (ES) cells SCR012. The resulting mice were crossed with FRT recombinase expression mice to delete the neo cassette. This mouse strain enables the Cre-mediated deletion of exon 2 and exon 3. (J:291061)