The targeting vector was designed to insert an internal ribosome entry site (IRES) fused to a codon improved cre recombinase (icre), followed by a frt-flanked neomycin resistance (neo) cassette in opposite orientation, immediately downstream of the stop codon in the 3' UTR. (J:101977)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count