The adenylate-uridylate-rich element (AU-rich element; ARE) and new regulatory element (NRE) in the 3' UTR were targeted with gRNAs (targeting GTGCAAATATAAATAGAGGG, TGCTTATGAATGTATTTATT, TTGTCTTAATAACGCTGATT and ATTTCTCTCAATGACCCGTA) using CRISPR/Cas9 technology, resulting in a 71 bp and a 76 bp deletion (TCTATTTATATTTGCACTTATTATTTATTATTTATTTATTATTTATTTATTTGCTTATGAATGTATTTATT and GCTGATTTGGTGACCAGGCTGTCGCTACATCACTGAACCTCTGCTCCCCACGGGAGCCGTGACTGTAATCGCCCTA). (J:306876)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Endonuclease-mediated
Intragenic deletion
--
1
3
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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