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CRISPR/Cas genome editing technology was used to generate a 49 nucleotide deletion of genomic sequences in exon 1, resulting in early termination in exon 2. Two founders were generated with no differences in experimental observations. The loss of OTOP1 protein in the homozygous mutants was verified by immunostaining using OTOP1 antibodies. (J:293042)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
