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A targeting construct was designed to insert an internal ribosomal entry site (IRES) and a Cre Recombinase with a polyadenylation signal, followed by a frt-flanked neomycin resistance (neo) cassette, downstream of the stop codon of the corticotropin releasing hormone receptor 2 (Crhr2) gene. The neomycin resistance gene was subsequently removed by crossing with Act-Flpe mice. (J:298576)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
