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The transgenic construct contains mouse Runx1 enhancer element sequence (eR1) also called Runx1 +24 mouse conserved noncoding element (mCNE) and the mouse Hspa1a (heat-shock protein 68) basal promoter sequence driving the expression of EGFP. Three distinct founder lines numbered 523, 540, and 542 were established. Although variation in the intensity of GFP fluorescence was observed, all three lines showed similar reporter gene expression patterns at sites of hematopoietic stem cell emergence in embryos. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:307859)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
