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The transgenic construct contains mouse Runx1 enhancer element sequence (eR1) and the mouse Hspa1a (heat-shock protein 68) basal promoter sequence driving the expression of cre/ERT2. More than 10 founder lines were generated. The line TG(5-2) with higher copy number and TG(3-7) with lower copy number used for studies. Although the former had higher Cre recombinase activity than the latter, the results obtained using these lines were qualitatively indistinguishable. (J:299420)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
