The targeting construct contains from 5' to 3': a loxP site, an FRT-flanked neomycin cassette upstream of exon 2 followed by a second loxP site downstream of exon 2. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:307193)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count