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EN
CRISPR/Cas9 endonuclease-mediated genome editing is used to create a F352V missense mutation (TTT to GTT). Guide RNAs (TTCTCAGATTCAGTAAAATC and ATTTTACTGAATCTGAGAAG) were selected to target position 352 of exon 2. The mutation corresponds to a human mutation associated with decreased susceptibility to late-onset Alzheimer's disease. (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
