A loxP site was inserted upstream of exon 1 and a second loxP site into intron 1. The loxP sites are approximately 1.9 kb apart and flank the start codon-containing first exon. The FRT site flanked neomycin resistance gene cassette that was also inserted, was removed through subsequent flp-mediated recombination. (J:236636)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count