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The targeting construct consisting of a CAG promoter, a loxp, 2xpA, FRT-flanked Pgk-neo selection cassette, STOP cassette, loxp, followed by a hM3Dq/mCherry fusion protein, pA signal all inserted into the Gt(ROSA)26Sor locus was used to generate the mouse line by homologous recombination in the C57BL/6N ES cells. The pgk-Neo cassette was removed with FLP66. CAG promoter drives expression of hM3Dq-mCherry only after Cre-mediated excision of the floxed stopper element. (J:294111)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
