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A construct comprising the following elements was inserted into the Gt(ROSA)26Sor locus: CAG promoter, a FRT site, a neomycin resistance gene cassette, a STOP cassette, a FRT site, the constitutionally active mutant form of simian TGFB1 cDNA containing the two point mutations C223S/C225S (TGFCA), IRES sequence, the eYFP fluorescent reporter gene, and bGH poly(A) sequence. The inserted TGFCA gene and the reporter gene will only be expressed after removal of the neo-STOP cassette through flp-mediated recombination. (J:294598)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
