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The mutation is a deletion of exons 317 and part of exon 18 by replacing them with a sequence encoding for enhanced green fluorescent protein (EGFP) followed by a human growth hormone polyadenylation sequence and a neomycin resistance cassette. EGFP expression was not detected in the mutant animals. Endogenous Plexin-B3 mRNA and Plexin-B3 protein expression was undetectable via RT-PCR and Western blot analysis respectively, in brains of 4-week-old homozygous mice. (J:307447)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
