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The targeting vector is designed to replace exons 3-6 (encoding the C-terminal half of the CARD and the entire CARD19 C-terminus) with a betageo-puro cassette. Absence of full-length protein expression was confirmed by western blot analysis of homozygous CD8+ T cells. Subsequent RNAseq and western blotting revealed hypomorphic expression of the adjacent Ninj1 gene. (J:307276)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
