A targeting construct comprised of 1.5 kb flanking homology arms, floxed exon 3, and a flippase recombination targetflanked neomycin resistance cassette replaced endogenous Adamts5 sequences by CRISPR/Cas9-mediated homologous recombination in ES cells. (J:298707)
Basic Information
(C57BL/6 x 129S4/SvJae)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count