Npvf^{tm1.1(icre)Gand}

Using homologous recombination in mouse embryonic stem cells, an internal ribosomal entry sequence (IRES) linked to an improved cre recombinase gene and an FRT-flanked neomycin resistance gene was targeted into the 3' untranslated region immediately downstream of the termination codon within the Npvf gene. FLPe-deleter mice were crossed to remove the FRT-flanked neomycin selection cassette. (J:300737)