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EN
By homologous recombination targeting in ES cells, the exon (ENSMUSE00001275521) including the start codon was flanked by loxP sequences and was followed by a Pgk-neo cassette flanked by Frt sequences. The Pgk-neo cassette was removed by crossing with Rosa-Flp mice. Mice were crossed to mice expressing cre in germline to delete the exon containing the start codon. Western blot analysis confirmed the absence of protein expression in newborn ovaries from homozygous mutant females. This is a null allele. (J:282136)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
