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CRISPR/cas9 endonuclease-mediated genome editing is used to insert a hemaglutinin (HA) tag and stop codon into exon 18 (the cytoplasmic domain). Western blot analysis confirms that the mutation results in decreased protein levels in brain, heart, lung, liver and spleen. (J:306272)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
