The targeting construct introduced a loxP site 68 bp upstream of exon 1 and a floxed neomycin resistance cassette downstream of exon 1. Cre-mediated recombination removed the selection cassette and left exon 1 floxed. (J:306439)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count