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The targeting vector introduced loxP sites flanking mouse Meis2 exon 3 and FRT-PGK-gb2-neo-FRT cassette. The targeting vector was electroporated into ES cells. Chimeras were generated by ES cell aggregation. The neomycin resistance cassette was eliminated by crossing with a Flpe deleted mouse. Deletion of this exon results in a premature stop codon, which eliminates all functional domains of the Meis2 protein. (J:301894)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
