By homologous recombination, an Internal ribosome entry site (IRES)-CRE-FRT-Neomycin-FRT cassette was inserted just downstream of the Glp1r stop codon. The generated knock-in mice were bred with a flippase (FLP)-deleter strain to remove the neomycin selection cassette. (J:302161)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count