Log In|Sign Up
EN
To reduce the expression of the betaA1-crystallin isoform without affecting the protein sequence, 5 base pairs (CCACC) were knocked-in before the first start codon to strengthen the Kozak consensus sequence (CCACCATGG) using CRISPR/Cas9 technology. Western blot analysis confirmed a decrease is the betaA1 isoform expression is astrocytes. (J:306517)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
