A F2A-icre was inserted into the 3' UTR of the Sp7 gene and a frt-flanked neo selection cassette was inserted into the nonconserved intron by homologous recombination in ES cells. The neo cassette was removed subsequently by Flp recombinase. (J:304652)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count