The targeting construct replaced the coding sequence in exon 1 with a cre/ERT2 fusion, polyadenylation sequence, and F3-flanked puromycin resistance cassette. Flp-mediated recombination removed the selection cassette. (J:266577)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count